Effects to your maternal bones was basically found in pregnant and you will lactating rats inside the a pre- and you can postnatal toxicity analysis when esomeprazole magnesium try administered at the dental dosages out-of 14 milligrams/kg/time to 280 milligrams/kg/date (on step 3.cuatro so you're able to 68 moments an oral individual dosage away from 40 mg to your a body surface basis). Whenever rats was basically dosed out-of gestational time 7 using weaning into the postnatal day 21, a mathematically extreme decrease in maternal femur lbs as much as 14% (than the placebo procedures) is noticed within dosage equivalent to otherwise more than 138 mg/kg/big date (throughout the 34 moments a dental peoples dose regarding 40 milligrams with the a human anatomy surface base).

An excellent pre- and postnatal advancement research into the rats that have esomeprazole strontium (having fun with equimolar amounts compared to the esomeprazole magnesium study) introduced equivalent contributes to dams and you can pups due to the fact described more than.